Vitamin B-1 is also known as Thiamine
, and is required to process
carbohydrates, fat and protein. It works best taken with Vitamin B-2 and B-3.
Thiamine aids digestion, optimizes cognitive functioning, and may help increase
energy. It is also an antioxidant and protects the body from the degenerative
effects of aging.
Vitamin B-2 or Riboflavin aids the body in the production
of red cells and is needed to process amino acids and fats. In addition, it
facilitates the use of oxygen in the tissues of the eyes, skin, nails and hair.
Niacin or Vitamin B-3 works with B-1 and B-2 to release energy
from carbohydrates. It is critical for proper blood circulation and healthy
skin. In addition, Niacin may lower cholesterol and help improve memory.
Pantothenic Acid or Vitamin B-5 is required to make the neurotransmitter
acetycholine. It is a vital body chemical necessary for many metabolic functions.
It is often used in the treatment of anxiety and depression, to enhance stamina,
and prevent certain types of anemia. B-5 works best when taken along with B-1,
B-2, and B-3.
Vitamin B-6 or Pyridoxine is essential for the processing
of amino acids, which are the building blocks of all proteins and some hormones.
It is used to treat water retention and is a mild diuretic often reducing the
symptoms of PMS.
Folic Acid also known as folate is a requisite for DNA synthesis.
It is also keeps homocysteine levels in the blood from rising. Since high homocysteine
levels are related to heart disease, osteoporosis, and Alzheimer's disease,
a proper amount of Folic Acid is imperative. Many people suffer from Folic Acid
deficiency. One study concluded that 10% of all coronary artery disease is attributable
to hyperhomocyteinemia. Increased Folic Acid intake might reduce the number
of cases of cardiovascular diseases in the United States alone by over 50,000
cases per year. (Ubbink JB, Becker PJ, Vermaak WJ. Will an increased dietary
folate intake reduce the incidence of cardiovascular disease? Nutr Rev, 54(7);
213-6, Jul 1996).
Iodine helps metabolize excess fat and is critical for mental
development. Iodine deficiency is the greatest single cause of preventable brain
damage and mental retardation in the world. (Delange F, Lecomte P. Iodine supplementation:
benefits outweigh risks. Drug Saf, Feb. 2000, 22:2). Iodine also supports a
healthy thyroid gland and prevents goiters. In addition, iodine deficiency has
been linked to breast cancer. A recent animal experiment found that iodine from
seaweed suppressed the proliferation of mammary tumors. (Funahashi H, et al.
Wakame seaweed suppresses the proliferation of 7,12-dmethylbenz (a)-anthracene-induced
mammary tumors in rats. Jpn J Cancer Res, 90:9,922-7, Sep 1999).
Vitamin E is a powerful antioxidant and free radical scavenger.
It protects the integrity of the cellular membranes in the body, and may help
reduce vaginal dryness. Vitamin E also enables estrogen, whether your own or
from hormone replacement therapy, to last longer, thus reducing hot flashes.
(Sandra Cabot, M.D., Smart Medicine for Menopause, Hormone Replacement Therapy
and its Natural Alternatives, Avery Publishing Group, Garden City New York,102-103,
Magnesium, in this formula, is chelated for enhanced absorption.
Magnesium activates enzymes required for numerous physiological functions including,
cardiac functions, metabolism of amino acids and fats, neuromuscular contractions,
regulation of acid-alkaline balance in the body, the utilization of calcium,
sodium, B-complex Vitamins, Vitamin C, and Vitamin E. (Altura B, et al. Magnesium
dietary intake modulates blood lipid levels and atherogenesis. Proc Natl Acad
Sci, Vol. 87: 1840-1844 Mar 1990).
Genistein, the principle isoflavonoid in soybeans, is reported
to reduce the risk of breast cancer. (Shao Zm, Wu J, Shen ZZ, Barsky SH. Address
given at theDepartment of Surgery, Cancer Hospital/Cancer Institute, Shanghai
Medical University. Cancer Res, 58(21): 4851-7 nov1, 1998). In addition the
mild estrogen activity of Genistein may ease menopause symptoms for some women,
without causing estrogen related problems. A study conducted in 1995 utilized
58 menopausal women who reported frequent hot flashes. Soy supplementation decreased
hot flashes by 40%. (Murkies AL, Lombard C, Strauss BJ, et al. Dietary flour
supplementation decreases post-menopausal hot flashes: Effect of soy and wheat.
Maturitas, 21(3): 189-95, 1995).
Borage Seed Oil (Borago officinalis) is recognized as nature's
richest source of gamma-linolenic acid (GLA). GLA has been demonstrated to promote
healthy bones and joints, reduce high blood pressure, enhance the immune system,
and reduce or eliminate the symptoms of certain types of eczema. (Levanthal
LJ et al. Treatment of rheumatoid arthritis with gammalinolenic acid. Ann Intern
Med, 119:867-73, 1993, and Borreck S, Hildebrandt A, Forster J. Borage seed
oil and atopic dermatitis. Klinische Pediatrie,203:100-104, 1993, and Engler
MM, Engler MB. Dietary borage oil alters plasma, hepatic and vascular tissue
fatty acid composition in spontaneously hyperactive rats. Prostaglandins Leukot
Essent Fatty Acids, 59(1): 11-5 Jul 1998).
Dong Quai (Angelica sinensis) is a traditional Chinese remedy
for regulating menstrual cycles, reducing cramping, and hot flashes. Although
Dong Quai does not have phytoestrogenic properties, it does have anti-spasmotic
properties especially on smooth muscles. (Qi-bing M., Jing-yi T, Bo C. Advance
in the phamacological studies of radix Angelica sinensis. Chin Med , 104; 776-81,1991).
Chaste Berry (Agnus-castus) has medicinally active components
that act upon the pituitary gland, specifically on the production of luteinizing
hormone. This acts to increase progesterone and helps regulate a woman's menstrual
cycle. A 1997 double blind placebo study found that Chaste Berry offered significant
relief for women suffering from symptoms of PMS, especially on breast tenderness,
cramping, and headaches. (Lauritzen CH, Reuter HD, Repges R. et al. Treatment
of premenstrual tension syndrome with Vitex agnus-castus. Phytomed, 4(3): 183-89,
Wild Yam (Dioscorea) is a storehouse of phytochemicals. Wild
Yam contains steroidal saponins that are pharmaceutically converted into cortisone,
estrogen, and progesterone-like compounds. Women who require progesterone should
consult a health professional and not rely solely on wild yam or other herbs.
Although the pharmaceutical conversion cannot be duplicated by the body, wild
yam offers many other benefits. Wild yam is considered to be a strong antispasmodic
and has potential anti-inflammatory properties. An extract of wild yam has been
shown to exhibit antioxidant properties, and has been shown to lower blood triglycerides
and to raise HDL, the "good" cholesterol. (Araghiniknam M, Chung S,
Nelson-White T, et al. Antioxidant activity of dioscorea and dehydroepiandrosterone
(DHEA) in older humans. Lif Sci, 11:147-57, 1996).
Black Cohosh (Cimicufuga racemosa) is used to promote health
during menopause. A review of eight human studies on the effectiveness of Black
Cohosh concluded that it is a safe and effective alternative to estrogen replacement
therapy for women. (Lieberman s. A review of the effectiveness of Cimicifuga
racemosa for the symptoms of menopause. J Womens Health, 7(5): 525-9, Jun 1998).
Uva Ursi (Arctostaphylos uva-ursi) is most often used for
urinary tract infections. A double blind study followed 57 women for one year.
Half were given a placebo and the other half received Uva-ursi. None of the
women taking Uva-ursi developed a bladder infection, while five of the untreated
women did. (Larson B, et al. Prophylactic effect of UVA-E in women with recurrent
cystitis: A preliminary report. Curr Ther Res 53:441-443, 1993).
Red Raspberry (Rubus Idaeus) has been used in folk medicine
as a female tonic for relieving excessive menstrual flow (menorrhagia), to relive
nausea, prevent nausea, prevent spotting, to tone the uterus in preparation
for childbirth, and to reduce the pain of childbirth. It has also been used
to relieve diarrhea, flu and vomiting. The PDR for Herbal Medicines (First Edition,1104-1105,
1998) indicates its use for disorders of the gastrointestinal tract, respiratory
tract, the cardiovascular system and the mouth and throat. In addition the German
Commission E monograph recommends the use of Red Raspberry in modern herbal
medicine. (Blumenthal M, Busse WR, Golberg A, et al, eds. The Complete Commission
E Monographs: Therapeutic Guide to Herbal Medicines. Boston, MA: Integrative
Medicine Communications, 366,1998.)
Passion Flower (Passiflora incarnata) is often used as a sedative
and antispasmodic. Also found in our Sleep Support formula. A double-blind,
placebo-controlled study found that it played a role in the treatment of "adjustment
disorder with anxious mood". (Bourin M, Bougerol T., Guitton B, Broutin
E. A combination of plant extracts in the treatment of outpatients with adjustment
disorder with anxious mood: controlled study versus placebo. Fundam Clin Pharmacol,
11(2): 127-32, 1997).
Alfalfa (Medico sativa) along with Salvia officinalis (Sage)
was found to be an effective agent in the treatment of menopausal symptoms.
Hot flashes, insomnia, nocturnal sweating, dizziness, headaches, and palpitations
are related to estrogen deprivation. A 1998 study utilizing 30 menopausal women
concluded that Medicago sativa and Salvia officinalis supplementation enabled
20 women to be completely relieved of hot flashes and night sweating, four women
reported good improvement, and six others showed a reduction in symptoms. No
adverse side effects were noted in the study. (De Leo V, Lanzetta D. Cazzavacca
R, Morgante G. Treatment of neurovegetative menopausal symptoms with a phytotherapeutic
agent. Minerva Ginecol, 50(5): 207-11 May 1998).
Citrus Bioflavonoids are natural substances found in citrus
fruits. Bioflavonoids help protect capillaries, prevent bruising and intensify
the effect of Vitamin C. In addition to Vitamin C, Citrus Bioflavonoid provide
folic acid, potassium, pectin, and many phytochemicals. (Craig WJ. Phytochemicals:
guardians of our health. J Am Diet Assoc, 97 (10 Suppl2): S199-204 Oct 1997).
Red Clover (Trifolium pratense) contains high levels of isoflavone
compounds such as Genistein, which have estrogenic properties. Researchers at
the Baker Medical Research Institute in Melbourne, Australia concluded that
the heightened cardiovascular risk associated with menopause can be reduced
by increasing dietary isofalvones. (Nestel PJ, Pomeroy S, Kay S, Komesaroff
P, Behrsing J, Cameron JD, West L.Isoflavones from red clover improve systemic
arterial compliance but not plasma lipids in menopausal women. J Clin Endocrinol
Metab, 84 (3) 895-8 Mar 1999
Motherwort (Leonurus Cardiaca) is most often recommended for
problems associated with menopause, PMS, mood swings, hot flashes, heart problems,
and blood clots. Various parts of Motherwort have been used traditional in Chinese
medicine for several thousand years. During the time of the Roman Empire the
plant was named Lion's Tail because of the shape of its shaggy leaves. Two recent
studies indicate its favorable clinical impact on blood flow, and support of
a healthy uterus. (Chang WC, Wong YC, Kong YC, Chun YT, Chang YT, and Chan WF.
Clinical observation on the uterotonic effect of I-mu Ts'ao. Am J Chin Med,
11(1-4): 77-83, 1983 , and Zou QZ, Bi RG, Li JM, Feng JB, Yu AM, Chan HP, Zhen
MX. Effect of motherwort on blood hyperviscosity, Am J Chin Med 17(1-2): 65-75,
Sage (Salvia officinalis) contains plant estrogens and has
been shown to be beneficial for women during menopause. Sage has an anti-perspiration
and drying effect and is helpful for women suffering from night sweating due
to menopause. (Weiss RF Herbal Medicine. Beaconsfield, UK: Beakonsfield Publishers
Ltd., 229-30, 1988).
Altura B, et al. Magnesium dietary intake modulates blood lipid levels and
atherogenesis. Proc Natl Acad Sci; Vol. 87: 1840-1844 Mar 1990.
Araghiniknam M, Chung S, Nelson-White T, et al. Antioxidant activity of dioscorea
and dehydroepiandrosterone (DHEA) in older humans. Lif Sci; 11:147-57, 1996).
Lauritzen CH, Reuter HD, Repges R. et al. Treatment of premenstrual tension
syndrome with Vitex agnus-castus. Phytomed; 4(3): 183-89, 1997.
Lieberman S. A review of the effectiveness of Cimicifuga racemosa for the symptoms
of menopause. J Womens Health; 7(5): 525-9, Jun 1998.
Liu J; Burdette JE; Xu H; Gu C; van Breemen RB; Bhat KP; Booth N; Constantinou
AI; Pezzuto JM; Fong HH; Farnsworth NR; Bolton JL. Evaluation of estrogenic
activity of plant extracts for the potential treatment of menopausal symptoms.
J Agric Food Chem; 49(5): 2472-9, May 2001.
Mukes AL, Wicox G, and Davis SR. Phytoestrogens. J Clin Endocrinol Metab; 83
(2): 297-303 Feb 1998.
Murkies AL, Lombard C, Strauss BJ, et al. Dietary flour supplementation decreases
post-menopausal hot flashes: Effect of soy and wheat. Maturitas; 21(3): 189-95,
Sandra Cabot, M.D., Smart Medicine for Menopause, Hormone Replacement Therapy
and its Natural Alternatives, Avery Publishing Group, Garden City New York,
Ubbink JB, Becker PJ, Vermaak WJ. Will an increased dietary folate intake
reduce the incidence of cardiovascular disease? Nutr Rev; 54(7); 213-6, Jul