MDHealthline

The ingredients found in MD Healthline's Total Health™ have been subjected to numerous scientific tests, which have clearly demonstrated the effectiveness and efficacy of this potent well health formula.

L- Glutamine
Total Health™ contains L-Glutamine. In a study reported in Life Extension: Disease Prevention and Treatment Protocols,L-Glutamine was demonstrated to be an "important metabolic substrate of rapidly proliferating cells. It influences the cellular hydration (combined with water) state and has multiple effects on the immune system, intestinal function, and protein metabolism." In a clinical human study involving bone-marrow transplant patients, Glutimine supplementation decreased the incidence of infections and shortened the hospital stay. In critically ill patients, Glutamine reduced nitrogen loss and caused a reduction of the mortality rate.

PHOSPHATIDYL SERINE
Phosphatidyl Serine plays an important role in maintaining the integrity of brain cell membranes. The breakdown of brain cell membranes prevents glucose and other nutrients from entering the cell. By protecting the integrity of brain cell membranes, Phosphatidyl Serine facilitates the efficient transport of energy-producing nutrients into cells, thus enhancing brain cell energy metabolism. To date, eleven double blind studies have been completed using Phosphatidyl Serine in the treatment of age-related cognitive decline, Alzheimer's disease, and depression. In the largest study conducted by T. Cenacchi et al, reported in Aging 5 (1993): 123-33, four hundred ninety four elderly patients with moderate to severe senility were given either Phosphatidyl Serine or a placebo for six months. The patients were assessed for mental performance, behavior, and mood at the beginning and end of the study. Statistically significant (p<0.01) improvements were noted in mental function, mood, and behavior in the Phosphatidyl Serine -treated group. Other studies indicating the efficacy of Phosphatidyl Serine for anti-aging include: R.R. Engel et al. "Double Blind Cross-Over Study of Phophatidyl Serine vs. Placebo in Patients with Early Dementia of the Alzheimer Type." Eur Neuropsychopharmacol 2 (1992): 149-55 and T.H. Crook et al., Effects of Phosphatidyl Serine in Age-Associated Memory Impairment, Neurology 41 (1991): 644-9.

CHRYSIN
Chrysin is a naturally occurring isoflavone chemically extracted from the plant Passiflora coerulea. Chrysin has been shown to be beneficial in reducing fat while maintaining lean body muscle. Chrysin has been popularized by European Olympic athletes attempting to build drug- free muscles. Chrysin may have other beneficial uses as well. In a recent article published by HK Wang et al entitled "Recent advances in the discovery and development of flavonoids and their analogues as antitumor and anti-HIV agents" published in Adv Exp Med Biol, 439:191-225, 1998, the researchers found that Chrysin along with other flavonoids " provide a continuing source of potential antitumor and anti-HIV agents."

NARINGININE
Naringinine is a powerful antioxidant citrus extract that inhibits free radical damage, acts as source of soluble fiber (pectin) to lower LDL cholesterol, and offers appetite reduction properties. As a Citrus Flavinoid, Naringines has been shown to inhibit enzymes called cytochrome P450. Excessive CYP450 in the system is associated with obesity. Leptin, a hypothalamus hormone, is integrally involved in appetite control, weight maintenance, and lowering the levels of CYP450. A hormone from the thyroid gland (throxine) is involved in fat breakdown and metabolism. Research indicates that a 60% to 80% reduction in CYP450 when throxine is increased.

References:

Ahnfelt-Ronne I; Haahr PM. New growth hormone secretagogues: from physiology to the first therapeutic applications. Arch Pediatr;5 Suppl 4:390S-396S, 1998.

Aleman A; de Vries WR; de Haan EH; Verhaar HJ; Samson MM; Koppeschaar HP. Age-sensitive cognitive function, growth hormone and insulin-like growth factor 1 plasma levels in healthy older men. Neuropsychobiology;41(2):73-8, Jan 2000.

Crook, T.H. et al., Effects of Phosphatidyl Serine in Age-Associated Memory Impairment, Neurology 4: 644-9, 1991.

Engel, R. R. et al. "Double Blind Cross-Over Study of Phophatidyl Serine vs. Placebo in Patients with Early Dementia of the Alzheimer Type." Eur Neuropsychopharmacol 2 :149-55 , 1992.

Fraser, Dr. Robert, "Tribulus Terrestris…a remarkable herb… Insight, page 8, March 1998.

Shalet SM, GH deficiency in the elderly: the case for GH replacement. Clin Endocrinol (Oxf);53(3):279-80, Sep 2000.

Wang. H. K. et al. "Recent advances in the discovery and development of flavonoids and their analogues as antitumor and anti-HIV agents." Adv Exp Med Biol, 439:191-225, 1998.

Van Cauter E; Leproult R; Plat L. Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men. JAMA;284(7):861-8, August 2000.